Nicotine Risk Factors. A Systematic Review of Preclinical Toxicology Evidence - Gustavo A. Olaiz Fernández

We conducted a systematic review (1990 to 2019) that focused on searching, collecting, and analyzing published data, using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) questionnaires and methods, in toxicological studies in animals, in vitro, in culture, cellular arrays, and computer models, with the aim of analyzing and organizing the scientific basis of knowledge on toxicity, evaluating the consistency of the designs used, strength of each methodology, model applied for data collection and treatment, as well as reproducibility of results.