"Smile Study" From the Center of Excellence for the Acceleration of Harm Reduction - Marilena Marchetti

Although the detrimental effects of conventional combustible cigarettes on oral health and dental esthetics are well known, there is limited information about the long-term impact of combustion-free nicotine alternatives (C-F NA) such as e-cigarettes or heated tobacco products. This multicenter, prospective, 3-parallel-arm randomized controlled trial will investigate whether switching from combustible cigarettes to C-F NA will lead to measurable improvements in oral health parameters and dental esthetics over 18 months in adult smokers with limited gum disease. Participant recruitment began in October 2021, and enrollment was completed in June 2023. Results will be reported in 2025. This will be the first study to provide key insights into oral health benefits or risks associated with using C-F NA in smokers who are seeking alternatives to cigarette smoking. https://pubmed.ncbi.nlm.nih.gov/38393754/